Thursday, November 15, 2018

GNR


Vijaysree Venkatraman has a nice article on Prof. G.N.Ramachandran's work at the University of Madras in the fifties and the sixties: How a Madras scientist won the global race in the ’50s to crack the structure of collagen. An excerpt:

First, he needed to find a source of collagen. The shark fin collagen from the biochemistry department on campus didn’t yield great images. Good quality pictures were essential to cracking the collagen puzzle, he knew. Leather, it occurred to GNR, was largely collagen.

Not far from the university campus was a new institute – the Central Leather Research Institute. GNR decided to pay his neighbours a visit. As he made his way there, the leather choices in GNR’s mind were Kangaroo Tail Tendon or Beef Achilles Tendon. The deputy director of CLRI turned out to be a kindred soul, happy to help a fellow scientist. The beef sample was easy to obtain locally. But if kangaroo collagen was going to yield the best diffraction images – as the scientific literature said – the deputy director promised to get GNR samples from Australia.

Thus, GNR found himself some purified marsupial collagen to work with.

The only information available on the fibrous protein collagen was this: one-third of its total amino acid content was glycine. Using this fact, looking at the pictures he had taken, GNR made an intuitive leap. [...]

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