Critics raise various concerns, but in my view the serious dispute about antidepressant efficacy has a limited focus. Do they work for the core symptoms (such as despair, low energy and feelings of worthlessness) of isolated episodes of mild or moderate depression? The claim that antidepressants do nothing for this common condition — that they are merely placebos with side effects — is based on studies that have probably received more ink than they deserve.
More here. A rebuttal of sorts to the NYRB articles by ex-JAMA editor Marcia Angell [See this post for links. Thanks to commenter Vijay for the pointer ]
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