With her first post-doc not working out well, TGFI is looking for a job. She has a must-read post on what went wrong, on the lessons learned, and on what she'll do differently this time. Here's one of her pieces of advice:
2) Do not start off with two high risk projects. Plan such that one project is in my area of expertise, the other can be a discovery/broadening horizons/learning new techniques experience.
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From the very interesting Tomorrow's Professor blog, here's some advice for new faculty: Management for Beginners - So You're a Principal Investigator - Now What?