Tejaswi lists some of the classic eateries in South Bangalore, with a promise to cover other parts soon. In Malleswaram (in the northern part that includes IISc), my favorite is the Janata Cafe on the 8th Cross Street. The Iyer mess is also fabulous.
The last couple of years has seen the opening of some pretty nice places in Malleswaram. Food Camp from the legendary Asha Sweets group (10th Cross and First Main) and Adiga's (15th Cross and Sampige Road) come to mind immediately.
My own favorite in our Institute's neighbourhood is Megh Sagar (at the Bashyam Circle, Sadashiva Nagar). Several new outlets have come up near this place: Daily Bread (for fancy sandwiches and cakes) and Namdharis (for wonderful salads) are great. They also sell all kinds of imported goodies; a liter of Evian, for example, costs just Rs. 125!
Over on the other side of the Institute, there has been a veritable explosion of shops and restaurants on New BEL Road near the Ramaiah Hospital. The Neel restaurant on the 80-feet Road is our favorite for taking our guests out to -- when someone else is footing the bill!
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I would love to check out the South-Bangalore places listed by Tejaswi, but for the dreadful traffic ...